The Two-Component System ChtRS Contributes to Chlorhexidine Tolerance in Enterococcus faecium
نویسندگان
چکیده
منابع مشابه
RNase 7 Contributes to the Cutaneous Defense against Enterococcus faecium
BACKGROUND Human skin is able to mount a fast response against invading microorganisms by the release of antimicrobial proteins such as the ribonuclease RNase 7. Because RNase 7 exhibits high activity against Enterococcus faecium the aim of this study was to further explore the role of RNase 7 in the cutaneous innate defense system against E. faecium. METHODOLOGY/PRINCIPAL FINDINGS Absolute q...
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Affiliations: 5 1 Department of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, 6 University of Melbourne, Victoria, 3010, Australia. 7 Infectious Diseases and Microbiology Departments, Austin Health, Heidelberg, Victoria, 3084, Australia. 8 Australian Collaborating Centre for Enterococcus and Staphylococcus Species (ACCESS) Typing and 9 Research, School of ...
متن کاملReduced Chlorhexidine and Daptomycin Susceptibility in Vancomycin-Resistant Enterococcus faecium after Serial Chlorhexidine Exposure
Vancomycin-resistant Enterococcus faecium strains (VREfm) are critical public health concerns because they are among the leading causes of hospital-acquired bloodstream infections. Chlorhexidine (CHX) is a bisbiguanide cationic antiseptic that is routinely used for patient bathing and other infection control practices. VREfm are likely frequently exposed to CHX; however, the long-term effects o...
متن کاملThe VanS-VanR two-component regulatory system controls synthesis of depsipeptide peptidoglycan precursors in Enterococcus faecium BM4147.
Plasmid pIP816 of Enterococcus faecium BM4147 confers inducible resistance to vancomycin and encodes the VanH dehydrogenase and the VanA ligase for synthesis of depsipeptide-containing peptidoglycan precursors which bind the antibiotic with reduced affinity. We have characterized a cluster of five genes of pIP816 sufficient for peptidoglycan synthesis in the presence of vancomycin. The distal p...
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ژورنال
عنوان ژورنال: Antimicrobial Agents and Chemotherapy
سال: 2017
ISSN: 0066-4804,1098-6596
DOI: 10.1128/aac.02122-16